CHRPE is a benign lesion which is present from birth, pigmented, has well-defined borders, and can gradually depigment in a lacunar fashion over time. Most (typical) CHRPE lesions carry no significance to the patient and, once diagnosed, no follow-up is generally necessary.
However some (atypical) CHRPE lesions can be associated with colonic polyposis syndromes and in certain cases, referral for screening colonoscopy is appropriate.
CHRPE lesions can undergo malignant transformation but this is felt to be extremely rare.

