Visual Improvement After Ocriplasmin for Vitreomacular Adhesion

This report from the largest studies on ocriplasmin discusses patient reported visual function after ocriplasmin injection. The conclusion is that more patients receiving ocriplasmin than placebo experienced meaningful improvement in visual function. But these proportions were 36% and 27% respectively – that’s a difference of just 9%.

My first reaction to this is that a £2500 injection that only produces meaningful visual function improvement in a third of patients is not very effective in absolute terms.

My second reaction is to ask why over a quarter of patients injected with placebo (i.e. no active medicine) also developed a meaningful visual function improvement?!